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Pharmaceutics and Pharmacology, The Ohio State Univ, Columbus, OH
Introduction: Dofetilide is a delayed rectifier potassium channel inhibitor utilized to take care of clients with atrial flutter and fibrillation, as well as its usage is connected with a threat of QT prolongation and Torsades de Pointes. The mechanisms tangled up in dofetilideвЂ™s renal tubular release and its uptake into cardiomyocytes stay unknown. Formerly reported drug-drug connection (DDI) studies recommend the participation of natural cation transporters. right Here, we investigated the share of natural cation transporters (OCT2 and MATE1) to your pharmacokinetics of dofetilide to get understanding of its DDI potential. (more…)